Fragment-based Drug Discovery PDF
By:Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Published on 2016-02-23 by John Wiley & Sons
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
This Book was ranked at 29 by Google Books for keyword Discovery.
Book ID of Fragment-based Drug Discovery’s Books is tjfvCQAAQBAJ, Book which was written byDaniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkershave ETAG “31qQpzYVmXs”
Book which was published by John Wiley & Sons since 2016-02-23 have ISBNs, ISBN 13 Code is 9783527337750 and ISBN 10 Code is 352733775X
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Book which have “528 Pages” is Printed at BOOK under CategoryMedical
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